<aside> 💭 Our goal at Pathomics is to create simplicity from complexity. We deliver a comprehensive suite of AI-based computer vision in an easy to use interface, the Pathomics Insight Engine, which enables decision makers to extract meaningful insights from rich multiplex datasets

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<aside> 💭 We are providing this wiki as a community resource in order to provide the open-source community with a single place from which to look up any published open-source code (and associated publications), to promote visibility and encourage discussion and collaboration between groups working in this field. The current iteration is curated, as there are a limited number of login accounts allowed in Notion, but we will migrate at an appropriate time to a more user-editable format, allowing each contributor to maintain and update their own entries to the catalog. In order to input an entry, go to https://bit.ly/PathomicsAddtoWiki and fill in the appropriate information.

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Contents

Inputs

Image Formats and Conversion

Image normalization

Image alignment


Pre-analytical processing

Manual annotation

Tissue type discrimination / ML

Stain deconvolution


Segmentation

Nuclear, cytoplasm, membrane, cell segmentation

Open source packages and commercial solutions


Classification

Supervised: Manual gating and associated visualization methods

Unsupervised: Dimensionality reduction, clustering


Post-processing Analytics

Spatial relationships between tissue regions (blood vessels, edge of tumor, hypoxia and necrosis

Cellular neighbourhood classification


Statistical and bioinformatics analysis

Registration and alignment with other imaging modalities

Bioinformatic analysis / combination with genomics / other technologies